Publications

Key Advantages of Sinnais™ Metronomic Deliverys

In contrast to the current standard of intraventricular drug delivery to the brain in which the therapeutic is delivered in a single bolus repeated at long intervals (of days or weeks), resulting in significant swings in the concentration of the delivered therapeutic, SINNAIS is designed for metronomic delivery, which is the delivery of sub-microliter-level amounts of drugs at consistently repeating rates. SINNAIS’s proprietary, state-of-the-art piezoelectric pump is capable of delivering precise microliter doses according to a preprogrammed and scheduled regimen.

Third-party studies and supporting clinical data have found that metronomic delivery keeps therapeutic drug levels within acceptable ranges and minimizes peak toxicity levels associated with the maximum toxicity of bolus delivery model, and that it also enables keeping a drug within a desired range of concentrations for an extended period of time, which may improve efficacy of treatment and reduce adverse side effects to patients. References to such treatment can be found in both pre-clinical studies and clinical trials.