Publications
Key Advantages of SINNAIS™ Metronomic Deliveries
In contrast to the current standard of intraventricular drug delivery to the brain in which the therapeutic is delivered in a single bolus repeated at long intervals (of days or weeks), resulting in significant swings in the concentration of the delivered therapeutic, SINNAIS™ is designed for metronomic delivery, which is the delivery of sub-microliter-level amounts of drugs at consistently repeating rates.
Third-party studies and supporting clinical data have found that metronomic delivery keeps therapeutic drug levels within acceptable ranges and minimizes peak toxicity levels associated with the maximum toxicity of the bolus delivery model, and it enables keeping a drug within a desired range of concentrations for an extended period of time, which may improve efficacy of treatment and reduce adverse side effects. References to such treatment can be found in both pre-clinical studies and clinical trials.
