Benefits of Metronomic Delivery

Clinical data supports the therapy value of intraventricular delivery of drugs into the Cerebrospinal fluid (CSF). Specifically, intraventricular drug delivery is indicated to improve drug efficacy by enabling the drug to reach the various regions of the brain following the cerebrospinal fluid circulatory pathway, thus providing an efficient and uniform drug infusion into the brain. Cognos Therapeutics is a leader in the design and development of a technologically advanced implantable pump, SINNAIS™, which includes a smart shunt adapted to deliver an adjustable volume and concentration of drugs to the ventricles in the brain. The Cognos Therapeutics smart shunt further includes features that enable physicians to utilize metronomic delivery of drugs and obtain parametric data such as temperature, pressure, and PH from the CSF.  Notably, metronomic intraventricular drug delivery from SINNAIS™ implanted pump may be applicable in the delivery of various new biotherapeutics to the brain, thus launching a new frontier in clinical therapy.